C7698
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C7698
Sigma
Cycloheximide
from microbial, ≥94% (TLC)
| Synonym: | 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A |
| CAS Number: | 66-81-9 |
| Linear Formula: | C15H23NO4 |
| Molecular Weight: | 281.35 |
| Beilstein Registry Number: | 88868 |
| EC Number: | 200-636-0 |
| MDL number: | MFCD00082346 |
| PubChem Substance ID: | 24892981 |
Description
| Biochem/physiol Actions | Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. |
Properties
| biological source | from microbial |
| assay | ≥94% (TLC) |
| solubility | ethanol: clear to hazy |
| Gene Information | human ... FKBP1A(2280), PIN1(5300) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+,N |
| Risk Statements | 61-28-51/53-68 |
| Safety Statements | 53-45-61 |
| RIDADR | UN2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | MA4375000 |
References
| reference | Obrig, T.G., et al. J. Biol. Chem. 246, 174, (1971) Abstract |
| Merck | Merck 13,2757 |
| Beilstein | Beil. 21,V,13,434 |
